Acute Care Volume 23, Issue 16

Medication Safety Alert! August 9, 2018

In this week’s issue:

Featured article

Methotrexate is a folic acid antagonist that was originally approved to treat a variety of cancers. Used for oncologic indications, methotrexate is administered in cyclical frequencies and in variable doses based on body surface area and the type of cancer being treated—for example, 12 g/m2 per dose when treating osteosarcoma. The labeled indications for methotrexate later expanded to include the treatment of nononcologic conditions, including psoriasis (approved in 1971) and rheumatoid arthritis (approved in 1988). Other nononcologic off-label uses include the treatment of Crohn’s disease,...

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