The following are excerpts from the newsletter

October 4, 2012

  • QuarterWatch™ (2012—Quarter 1)
    Signals for DULoxetine, pioglitazone, aliskiren, and rivaroxaban

  • Safety Brief: Topical analgesics and burns. The US Food and Drug Administration (FDA) told health professionals and the public last month that certain over-the-counter (OTC) topical products for the relief of mild muscle and joint pain have been reported to cause rare cases of serious skin injuries, ranging from first- to third-degree chemical burns

  • Safety Brief: Warning! Do not use unrefrigerated Avastin and Lucentis. ISMP became aware of a situation in which multiple intraocular injections of bevacizumab (AVASTIN) may have been used after they were accidentally left at room temperature for at least 2 days. According to Genentech, Avastin should be refrigerated after reconstitution but is stable for up to 24 hours at room temperature (9–25°C).

  • Safety Brief: Reducing emergency hospital admissions in the elderly. As of Monday October 1st, 2012 , Medicare begins fining hospitals for having too many patients readmitted within 30 days of discharge for treatment complications. Three conditions are being targeted: heart failure, myocardial infarction, and pneumonia.

  • ISMP webinar. Join us on October 24 for Challenges in Neonatal Intensive Care Medication Safety: Identifying Risk and Opportunity. For details, please visit:


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