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Promethazine conundrum: IV can hurt more than IM injection!

Survey spurs interest in renewing efforts to prevent serious tissue damage

From the November 2, 2006 issue


1) Friederich S. Westport woman settles hospital suit. The Daily World. August 30, 2006:

2) Phenergan (promethazine HCl) injection package insert. Deerfield, IL: Baxter Healthcare Corporation; 2005 (

3) Promethazine hydrochloride injection [package insert]. Irvine, CA: Sicor Pharmaceuticals Corp; 2004.

4) Malesker MA, Malone PM, Cingle CM, Cochran RM. Extravasation of IV promethazine. Am J Health-Syst Pharm 1999; 56: 1742-43.

Additional References

Infusion Nurses Society- Patient safety discussion forum. Phenergan. Discussion thread. Posted 23 February 2006.

Hohenhaus SM. An informal discussion of emergency nurses’ current clinical practice: what’s new and what works. Danger with use of intravenous promethazine in the emergency department. J of Emerg Nursing 2005; 31 (5): 465-467.

Strausser R. IV promethazine and tissue ulceration. Hosp Pharm 2002; 37(1): 33.

Pennsylvania Patient Safety Reporting System. Extravasation of radiologic contrast. Patient Safety Advisory 2004; 1 (3): 1-5.

Musician lost hand after drug instructions failed to warn. Available at: Accessed 28 July 2006.

Sen S, Chini EN, Brown MJ. Complications after unintentional intra-arterial injection of drugs: risks, outcomes, and management strategies. Mayo Clin Proc 2005; 80 (6): 783- 795.

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