Promethazine conundrum: IV can hurt more than IM injection!
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References

1) Friederich S. Westport woman settles hospital suit. The Daily World. August 30, 2006: http://www.thedailyworld.com/articles/2006/08/30/local_news/04news.prt.

2) Phenergan (promethazine HCl) injection package insert. Deerfield, IL: Baxter Healthcare Corporation; 2005 (http://www.baxter.com/products/anesthesia/anesthetic_pharmaceuticals/downloads/phenergan.pdf).

3) Promethazine hydrochloride injection [package insert]. Irvine, CA: Sicor Pharmaceuticals Corp; 2004.
http://www.sicor.com/products/pi/promethazine_7-2004_y36-000-52c.pdf.

4) Malesker MA, Malone PM, Cingle CM, Cochran RM. Extravasation of IV promethazine. Am J Health-Syst Pharm 1999; 56: 1742-43.

Additional References

Infusion Nurses Society- Patient safety discussion forum. Phenergan. Discussion thread. Posted 23 February 2006. http://listserv.npsf.org/SCRIPTS/WA-NPSF.EXE?A2=ind0602&L=patientsafety-l&P=14979.

Hohenhaus SM. An informal discussion of emergency nurses’ current clinical practice: what’s new and what works. Danger with use of intravenous promethazine in the emergency department. J of Emerg Nursing 2005; 31 (5): 465-467.

Strausser R. IV promethazine and tissue ulceration. Hosp Pharm 2002; 37(1): 33.

Pennsylvania Patient Safety Reporting System. Extravasation of radiologic contrast. Patient Safety Advisory 2004; 1 (3): 1-5.

Musician lost hand after drug instructions failed to warn. Available at: www.verdictsearch.com/jv3_news/newsletter/nat/033104/5.jsp. Accessed 28 July 2006.

Sen S, Chini EN, Brown MJ. Complications after unintentional intra-arterial injection of drugs: risks, outcomes, and management strategies. Mayo Clin Proc 2005; 80 (6): 783- 795.

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